Leeds Teaching Hospitals NHS Trust - Centre for Dermatology, Chapel Allerton Hospital, Leeds, LS7 4SA, UK.
Centre for Occupational and Environmental Health, University of Manchester, Manchester, M13 9PL, UK.
Contact Dermatitis. 2018 Jan;78(1):33-40. doi: 10.1111/cod.12902. Epub 2017 Oct 27.
Fragrances are well known to cause allergic contact dermatitis (ACD). Occupationally related cases occur, with certain groups being at higher risk.
To investigate the incidence of occupationally related cases of cutaneous fragrance allergy and to evaluate trends.
Data on incident cases of occupational ACD caused by fragrances between 1996 and 2015 (inclusive) reported to the EPIDERM surveillance scheme were analysed.
Of the cases reported to EPIDERM during the study period, 5.2% had ACD attributed to fragrances. The highest annual incidence rates were observed in women. Hairdressers, beauticians and people working in related occupations had a 47-fold higher incidence rate ratio than the reference category (the average of all other occupations combined). Trends analysis suggested a non-significant increase in fragrance allergy over the study period among all occupations, and beauty and food workers, and a slight decrease in healthcare workers.
Fragrance allergy is a significant problem in an occupational setting. Although there was no significant change in the incidence of fragrance-related allergic occupational contact dermatitis (OCD) during the 20-year study period, this does not mirror the trend in OCD, which is falling. Fragrance allergy continues to be a major contributor to OCD, and contributes to a greater proportion of cases.
香料众所周知会引起过敏性接触性皮炎（ACD）。职业相关的病例时有发生，某些群体的风险更高。
调查职业相关的皮肤香料过敏病例的发生率，并评估其趋势。
分析了 1996 年至 2015 年（包括）期间向 EPIDERM 监测计划报告的职业性 ACD 由香料引起的病例数据。
在所研究期间向 EPIDERM 报告的病例中，有 5.2%的病例归因于香料的 ACD。女性的年发病率最高。美发师、美容师和从事相关职业的人员的发病率比参照组（所有其他职业的平均水平）高出 47 倍。趋势分析表明，在整个研究期间，所有职业、美容和食品工人的香料过敏呈非显著上升趋势，而医护人员则略有下降。
香料过敏是职业环境中的一个重大问题。尽管在 20 年的研究期间，与香料相关的职业性接触性皮炎（OCD）的发病率没有显著变化，但这与 OCD 的下降趋势并不相符。香料过敏仍然是 OCD 的主要原因之一，占病例的比例更大。
