Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, 91054 Erlangen, Germany.
Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, 30625 Hannover, Germany.
Int J Environ Res Public Health. 2020 Apr 1;17(7):2404. doi: 10.3390/ijerph17072404.
Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals "Contact Dermatitis" and "Dermatitis" were manually searched, covering the years 2018-2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N'-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just cosmetics, must be put on the legislative agenda.
接触过敏（致敏）及其所致的过敏性接触性皮炎对公众健康有重大影响。本综述通过 Medline 和 Web of ScienceTM 系统地搜索了所有相关文章；此外，还手动搜索了“Contact Dermatitis”和“Dermatitis”期刊的所有可用期，涵盖了 2018-2019 年，从而扩展和重新聚焦了之前的类似综述。根据物质类别，如新的过敏原或在新的暴露环境中发现的以前描述过的过敏原，或具有其他当前重要性的过敏原，分别在各个部分进行描述，例如金属、防腐剂、香料。在许多研究中都有一个共同的发现，即产品成分信息的缺乏，例如在帆布鞋中发现的新过敏原（二甲基硫代氨基甲酰基苯并噻唑硫），尤其是血糖仪和胰岛素泵制造商缺乏合作，这两种设备分别因异冰片丙烯酸酯和 N，N'-二甲基丙烯酰胺的释放而导致相当数量的糖尿病患者出现严重的过敏性接触性皮炎，这一点已被皮肤科医生和化学家之间的国际合作所证明。必须将所有类型产品（不仅仅是化妆品）的改进和完整成分标签提上立法议程。
