Departments of Pathology.
Bioptic Laboratory Ltd.
Am J Surg Pathol. 2018 Feb;42(2):234-246. doi: 10.1097/PAS.0000000000000972.
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.
ETV6 基因异常在肿瘤病理学中已有很好的描述。在多种上皮、间充质和血液恶性肿瘤中，已经报道了 ETV6 的许多融合伙伴。然而，在唾液腺肿瘤病理学中，ETV6-NTRK3 易位是（乳腺样）分泌性癌的特异性，在任何其他唾液腺肿瘤类型中都没有记录。本研究对 10 例具有典型形态和免疫表型的分泌性癌进行了临床、组织学和分子分析，这些肿瘤均存在一种新型的 ETV6-RET 易位。
