Gamma glutamyl transferase in diabetic rats. The effect of insulin treatment.

In rats, streptozotocin-induced diabetes resulted in the increase of plasma gamma GT. A daily dose of 2 U protamine zinc insulin for two weeks did not affect the high levels of both gamma GT and glucose. Supplementation with 3 U insulin for only one week reduced both gamma GT and glucose levels. This indicates that insulin treatment could correct the rise of the enzyme level found in some diabetic patients.