Tahiliani A G, Lopaschuk G D, McNeill J H
Gen Pharmacol. 1984;15(6):545-7. doi: 10.1016/0306-3623(84)90213-1.
Six months following the induction of diabetes by streptozotocin (50 mg/kg i.v.) diabetic rats exhibited elevated levels of plasma glucose and glycosylated hemoglobin. Plasma insulin levels were 50% of control and diabetic animals weighed significantly less than control. Using a working heart preparation it was found that (+) and (-) dP/dt and left ventricular pressure development (LVDP) was decreased in hearts from diabetic animals. Insulin treatment (9 U/kg/day s.c. of protamine zinc insulin) for 4 weeks prior to sacrifice restored body weight and plasma insulin to normal. Plasma glucose and glycosylated hemoglobin levels were significantly decreased towards normal in insulin treated diabetic rats. LVDP and (+) dP/dt was also partially returned to normal in insulin treated diabetic rats while (-) dP/dt was completely reversed to normal. Thus, 4 weeks of insulin treatment to rats previously diabetic for 5 months partially or totally reversed the changes produced by diabetes.
用链脲佐菌素（50毫克/千克静脉注射）诱导糖尿病6个月后，糖尿病大鼠的血糖和糖化血红蛋白水平升高。血浆胰岛素水平为对照组的50%，糖尿病动物的体重明显低于对照组。使用工作心脏标本发现，糖尿病动物心脏的（+）和（-）dP/dt以及左心室压力发展（LVDP）降低。在处死前4周，用胰岛素（鱼精蛋白锌胰岛素9单位/千克/天皮下注射）治疗可使体重和血浆胰岛素恢复正常。胰岛素治疗的糖尿病大鼠的血糖和糖化血红蛋白水平显著下降至接近正常。胰岛素治疗的糖尿病大鼠的LVDP和（+）dP/dt也部分恢复正常，而（-）dP/dt完全恢复正常。因此，对先前患糖尿病5个月的大鼠进行4周的胰岛素治疗可部分或完全逆转糖尿病所产生的变化。
