用于无标记化学发光分析和分子逻辑操作的核酸外切酶辅助靶标循环扩增
Exonuclease-assisted target recycling amplification for label-free chemiluminescence assay and molecular logic operations.
作者信息
Yan Yongcun, Yue Shuzhen, Zhao Tingting, Luo Baoyu, Bi Sai
机构信息
Collaborative Innovation Center for Marine Biomass Fiber, Materials and Textiles of Shandong Province, College of Chemistry and Chemical Engineering, Laboratory of Fiber Materials and Modern Textiles, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, P. R. China.
出版信息
Chem Commun (Camb). 2017 Nov 9;53(90):12201-12204. doi: 10.1039/c7cc06835b.
A versatile exonuclease III (Exo III)-assisted target recycling amplification (Exo-TRA) strategy is demonstrated to achieve label-free and homogeneous chemiluminescence (CL) detection of target DNA. Inspired by this principle, a series of logic gates are constructed using DNA molecules as "inputs" to activate the Exo-TRA system.
一种通用的核酸外切酶III（Exo III）辅助靶标循环扩增（Exo-TRA）策略被证明可实现对靶标DNA的无标记均相化学发光（CL）检测。受此原理启发，一系列以DNA分子作为“输入”来激活Exo-TRA系统的逻辑门被构建出来。
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