Zeng Wen, Guo Yonghong, Wu Guofeng, Liu Xueyan, Fang Qian
Postgraduate College, Guizhou Medical University, 550025 Guiyang, China.
J Rehabil Med. 2018 Jan 10;50(1):8-15. doi: 10.2340/16501977-2287.
To evaluate the mean treatment effect of mirror therapy on motor function of the upper extremity in patients with stroke.
Electronic databases, including the Cochrane Library, PubMed, MEDLINE, Embase and CNKSystematic, were searched for relevant studies published in English between 1 January 2007 and 22 June 2017.
Randomized controlled trials and pilot randomized controlled trials that compared mirror therapy/mirror box therapy with other rehabilitation approaches were selected.
Two authors independently evaluated the searched studies based on the inclusion/exclusion criteria and appraised the quality of included studies according to the criteria of the updated version 5.1.0 of the Cochrane Handbook for Systematic Review of Interventions.
Eleven trials, with a total of 347 patients, were included in the meta-analysis. A moderate effect of mirror therapy (standardized mean difference 0.51, 95% confidence interval (CI) 0.29, 0.73) on motor function of the upper extremity was found. However, a high degree of heterogeneity (χ2 = 25.65, p = 0.004; I2 = 61%) was observed. The heterogeneity decreased a great deal (χ2 = 6.26, p = 0.62; I2 = 0%) after 2 trials were excluded though sensitivity analysis.
Although the included studies had high heterogeneity, meta-analysis provided some evidence that mirror therapy may significantly improve motor function of the upper limb in patients with stroke. Further well-designed studies are needed.
评估镜像疗法对中风患者上肢运动功能的平均治疗效果。
检索电子数据库，包括考克兰图书馆、PubMed、MEDLINE、Embase和中国知网系统，以查找2007年1月1日至2017年6月22日期间发表的英文相关研究。
选取比较镜像疗法/镜像箱疗法与其他康复方法的随机对照试验和试点随机对照试验。
两位作者根据纳入/排除标准独立评估检索到的研究，并根据《考克兰系统评价干预措施手册》第5.1.0版更新标准评估纳入研究的质量。
荟萃分析纳入了11项试验，共347例患者。发现镜像疗法对上肢运动功能有中度效果（标准化均数差0.51，95%置信区间（CI）0.29，0.73）。然而，观察到高度异质性（χ2 = 25.65，p = 0.004；I2 = 61%）。通过敏感性分析排除2项试验后，异质性大幅降低（χ2 = 6.26，p = 0.62；I2 = 0%）。
尽管纳入研究存在高度异质性，但荟萃分析提供了一些证据表明镜像疗法可能显著改善中风患者的上肢运动功能。需要进一步设计良好的研究。
