急性鼻-鼻窦炎鼻黏膜的病理和细胞变化：透明质酸的支持治疗作用。
Pathological and cytological changes of the nasal mucosa in acute rhinosinusitis: the role of hyaluronic acid as supportive therapy.
机构信息
Organi di Senso Department, "Sapienza" University of Rome, Rome, Italy.
出版信息
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4411-4418.
OBJECTIVE
The aim of this study was to evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS).
PATIENTS AND METHODS
48 patients affected by ARS were submitted to nasal endoscopy, nasal cytology, mucociliary transport evaluation (MCTt) and visual analogue scale questionnaire (VAS) at T0, after 14-18 days (T1) and after 30-35 days (T2). The patients were randomized into two groups, A and B, and received Levofloxacin and Prednisone. Moreover, using a nebulizer ampoule for nasal douche, Group A received high molecular weight Sodium Hyaluronate (3%) plus saline solution (NaCl 0.9%) twice a day for 30 days; Group B received saline solution twice a day for 30 days.
RESULTS
At T0 only the VAS score showed differences regarding nasal discharge and post-nasal drip. At T1, in Group A MCTt and the number of bacteria were significantly lower than in Group B. The VAS score showed improvement in Group A. At T2 in Group A, MCTt and number of neutrophils were significantly lower than in Group B. The VAS score showed statistically significant differences between the two groups regarding nasal discharge.
CONCLUSIONS
In ARS patients sodium hyaluronate plus saline solution significantly improved symptoms, MCT time and reduced neutrophil count on nasal cytology.
目的
本研究旨在评估透明质酸在急性鼻-鼻窦炎（ARS）中的修复作用。
患者和方法
48 例 ARS 患者在 T0 时接受鼻内窥镜检查、鼻细胞学检查、黏液纤毛传输时间（MCTt）和视觉模拟量表问卷（VAS）评估，然后在 14-18 天（T1）和 30-35 天（T2）时再次进行评估。患者随机分为两组，A 组和 B 组，接受左氧氟沙星和泼尼松治疗。此外，A 组使用鼻腔冲洗雾化器安瓿，每天两次接受高相对分子质量透明质酸钠（3%）加生理盐水（NaCl 0.9%）鼻腔冲洗 30 天；B 组每天两次接受生理盐水鼻腔冲洗 30 天。
结果
在 T0 时，只有 VAS 评分在鼻腔分泌物和后鼻滴注方面存在差异。在 T1 时，A 组的 MCTt 和细菌数量明显低于 B 组。A 组的 VAS 评分有所改善。在 T2 时，A 组的 MCTt 和中性粒细胞数量明显低于 B 组。A 组的 VAS 评分在鼻腔分泌物方面与 B 组有统计学差异。
结论
在 ARS 患者中，透明质酸钠加生理盐水显著改善了症状、MCT 时间，并减少了鼻细胞学检查中的中性粒细胞计数。
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