Department of Otorhinolaryngology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4292-4297.
CD14 is the cell surface glycoprotein, which plays an important role in the occurrence and development of tumors. This study was designed to assess the association between CD14 SNPs and laryngeal cancer risk.
This case-control study including 406 cases of laryngeal cancer and 893 healthy controls. The relationship between the genetic variation of CD14, rs2569190 and rs5744455, and the onset risk of laryngeal cancer were investigated. Logistic regression analysis was used to calculate the odds ratio (OR) and 95% confidence interval (CI) to study the relationship between CD14 gene polymorphism and pathogenesis of laryngeal cancer.
The results showed that rs5744455 mutation could increase the onset risk of laryngeal cancer (TT vs. CC: OR = 1.20, 95% CI = 1.01-1.41; additive model: OR = 1.20, 95% CI = 1.01-1.42). The results of stratified analysis showed that rs5744455 was associated with the susceptibility to laryngeal cancer in the elderly, females, non-smokers and non-drinkers (OR = 1.32, 95% CI = 1.04-1.66; OR = 1.58, 95% CI = 1.21-2.06; OR = 1.35, 95% CI = 1.08-1.69; OR = 1.31, 95% CI = 1.05-1.65). The analysis of combined effect of rs2569190 and rs5744455 showed that there was a combined effect between the two mutant loci (ptrend = 0.011).
This study suggested that the genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer, providing a theoretical basis for the study of the pathogenesis of laryngeal cancer.
CD14 是细胞表面糖蛋白，在肿瘤的发生和发展中起重要作用。本研究旨在评估 CD14 SNPs 与喉癌风险的关系。
本病例对照研究纳入 406 例喉癌患者和 893 例健康对照。研究 CD14 基因 rs2569190 和 rs5744455 的遗传变异与喉癌发病风险的关系。采用 logistic 回归分析计算比值比（OR）和 95％置信区间（CI），研究 CD14 基因多态性与喉癌发病机制的关系。
结果显示，rs5744455 突变可增加喉癌发病风险（TT 与 CC 相比：OR=1.20，95％CI=1.01-1.41；加性模型：OR=1.20，95％CI=1.01-1.42）。分层分析结果显示，rs5744455 与老年、女性、不吸烟者和不饮酒者的喉癌易感性相关（OR=1.32，95％CI=1.04-1.66；OR=1.58，95％CI=1.21-2.06；OR=1.35，95％CI=1.08-1.69；OR=1.31，95％CI=1.05-1.65）。rs2569190 和 rs5744455 联合效应分析显示，两个突变位点存在联合效应（ptrend=0.011）。
本研究提示 CD14 基因 rs5744455 遗传变异与喉癌易感性相关，为喉癌发病机制的研究提供了理论依据。
