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DIAPH2、PTPRD 和 HIC1 基因多态性与喉癌风险。

DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.

机构信息

Department and Clinic of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 41-800 Zabrze, Poland.

Department of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland.

出版信息

Int J Environ Res Public Health. 2021 Jul 13;18(14):7486. doi: 10.3390/ijerph18147486.

DOI:10.3390/ijerph18147486
PMID:34299935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8305316/
Abstract

UNLABELLED

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk.

PATIENTS AND METHODS

This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer.

RESULTS

The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups.

CONCLUSIONS

This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

摘要

目的

DIAPH2、PTPRD 和 HIC1 是细胞糖蛋白，在肿瘤的发生和发展中起重要作用。本研究旨在评估 DIAPH2、PTPRD 和 HIC1 SNP 与喉癌风险之间的关联。

患者和方法

本研究包括 267 例经组织学证实的喉癌患者和 157 例对照。研究了 DIAPH2(rs6620138)、PTPRD(rs3765142)和 HIC1(rs9901806)基因变异与喉癌发病之间的关系。统计分析计算 DIAPH2、PTPRD 和 HIC1 基因多态性与喉癌发病机制的关系。

结果

结果表明，DIAPH2(rs6620138)多态性可增加喉癌发病风险。DIAPH2(rs6620138)和 HIC1(rs9901806)的等位基因分布在病例组和对照组亚组中存在统计学显著差异。

结论

本研究结果表明，DIAPH2(rs6620138)多态性的遗传变异与喉癌易感性有关。我们的结果为开始研究 DIAPH2 基因在喉癌发病机制中的作用提供了基础。

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