Department of Human Pathology of Adult and Childhood "G. Barresi", Obstetrics and Gynecology Unit, University Hospital "G. Martino", Gazzi, Messina, Italy.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4270-4277.
To report the incidence and the major risk factors (RFs) associated with preterm birth (PTB), combining both maternal RFs and cervical length (CL), and to understand if cervical length measurement is really useful in all the patients.
The study population consisted of 2048 women admitted to the Department of Obstetrics and Gynecology, University Hospital of Messina, over a 2-year period. Preterm cases represented approximately 8.64% of our total population and, exactly, 65% were late preterm, 32% were preterm, and 3% were extremely preterm.
An analysis of PTB sub-categories based on gestational age showed a stronger correlation between gestational age and CL among preterm and extremely preterm, while no correlation was found among late preterm. Between preterm cases and controls, there was a significant difference in pre-pregnancy weight and Body Mass Index (BMI). Moreover, a significant association between PTB and uterine anomalies, poli-oligodramnios and hypertension was found.
We strongly suggest adding a transvaginal ultrasound CL universal screening to all pregnant women at the time of the second trimester ultrasound. We encourage further studies to identify new RFs of PTB and to define the mechanisms by which risk factors are related to PTB.
报告早产（PTB）的发生率和主要危险因素（RFs），同时结合母体 RFs 和宫颈长度（CL），并了解宫颈长度测量是否对所有患者都真正有用。
研究人群由 2048 名在墨西拿大学医院妇产科就诊的妇女组成，研究时间为 2 年。早产病例约占总人群的 8.64%，其中 65%为晚期早产，32%为早产，3%为极早产。
根据胎龄对早产亚类进行分析表明，在早产和极早产中，CL 与胎龄之间的相关性更强，而在晚期早产中则没有相关性。在早产病例和对照组之间，孕前体重和体重指数（BMI）存在显著差异。此外，还发现早产与子宫异常、多胎妊娠和高血压之间存在显著关联。
我们强烈建议在孕中期超声检查时对所有孕妇进行经阴道超声 CL 常规筛查。我们鼓励进一步研究以确定新的 PTB 危险因素，并确定危险因素与 PTB 之间的关系机制。
