Guerin M, Barrois M, Riou G
Institut Gustave-Roussy, Laboratoire de Pharmacologie moléculaire, Villejuif.
C R Acad Sci III. 1988;307(20):855-61.
The c-myb gene was studied in 112 breast cancers. c-myb and estrogen receptor (ER) transcripts were found in 78 (70%) and 71 (63%) cancers respectively. Of these 71 ER positive cancers, 64 (90%) contained c-myb transcripts and of the 41 ER negative cancers, 27 (66%) did not contain c-myb mRNA. Our data show that c-myb transcripts are strongly associated with ER and progesterone receptors (p less than 10(-4) status in breast cancer. Thus the c-myb expression could be associated with breast cancers of better prognosis and its analysis could allow a better characterization of new subsets of hormono-dependent cancers responding more efficiently to hormonotherapy.
对112例乳腺癌患者的c-myb基因进行了研究。分别在78例（70%）和71例（63%）癌症中发现了c-myb和雌激素受体（ER）转录本。在这71例ER阳性癌症中，64例（90%）含有c-myb转录本，而在41例ER阴性癌症中，27例（66%）不含有c-myb mRNA。我们的数据表明，c-myb转录本与乳腺癌中的ER和孕激素受体（p小于10⁻⁴）状态密切相关。因此，c-myb表达可能与预后较好的乳腺癌相关，对其分析有助于更好地刻画对激素治疗反应更有效的激素依赖性癌症新亚群。
