Guérin M, Sheng Z M, Andrieu N, Riou G
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy, Villejuif, France.
Oncogene. 1990 Jan;5(1):131-5.
Previous articles have reported that the c-myb proto-oncogene was activated in various types of tumours of the hematopoietic system suggesting that this gene plays a role in the development of these malignancies. However no studies of the c-myb gene have as yet been performed in solid primary tumours. In the present study we have analysed in breast cancer the c-myb gene with the aim to determine its involvement in tumour progression. Expression of the c-myb oncogene was analysed from 169 carcinoma specimens obtained from untreated patients with non-inflammatory breast cancer (NBC) (112 patients) and inflammatory breast cancer (IBC) (57 patients). A 3.5 kb c-myb transcript band was detected in 108 (64%) tumours. c-myb expression was found to be associated with good prognostic factors (lowest histopathologic grade (P = 0.01), oestrogen and progesterone receptor status (P less than 10(-4)) and pS2 gene expression (P less than 10(-4)) and negatively correlated with breast cancers of poorer prognosis, namely IBC (P = 0.03) and NBC with multiple involved nodes (P = 0.15). Other genes (c-myc, c-erbB2, c-fos and epidermal growth factor receptor) were also studied. The c-myb gene expression was found to be inversely correlated (P less than 0.03) with only c-erbB2 overexpression in NBC. When data were analysed with a logistic regression model using a stepwise procedure, c-myb expression was found to be associated only with the oestrogen receptor status (P less than 10(-4)). In conclusion, our data indicate that analysis of c-myb expression in breast cancer could allow the characterization of a new class of oestrogen-dependent tumours.
以往的文章报道，c-myb原癌基因在各种造血系统肿瘤中被激活，提示该基因在这些恶性肿瘤的发生发展中起作用。然而，尚未对实体原发性肿瘤中的c-myb基因进行研究。在本研究中，我们对乳腺癌中的c-myb基因进行了分析，旨在确定其与肿瘤进展的关系。对169例未经治疗的非炎性乳腺癌（NBC）（112例）和炎性乳腺癌（IBC）（57例）患者的癌组织标本进行了c-myb癌基因表达分析。在108例（64%）肿瘤中检测到一条3.5 kb的c-myb转录带。发现c-myb表达与良好的预后因素相关（最低组织病理学分级（P = 0.01）、雌激素和孕激素受体状态（P < 10^(-4)）以及pS2基因表达（P < 10^(-4)）），与预后较差的乳腺癌呈负相关，即IBC（P = 0.03）和有多枚受累淋巴结的NBC（P = 0.15）。还研究了其他基因（c-myc、c-erbB2、c-fos和表皮生长因子受体）。在NBC中，发现c-myb基因表达仅与c-erbB2过表达呈负相关（P < 0.03）。当使用逐步法通过逻辑回归模型分析数据时，发现c-myb表达仅与雌激素受体状态相关（P < 10^(-4)）。总之，我们的数据表明，分析乳腺癌中的c-myb表达可以鉴定出一类新 的雌激素依赖性肿瘤。
