Beckman Institute , 405 North Mathews Avenue, Urbana, Illinois 61801, United States.
Dendronex, LLC , 109 Runway Drive, Reese Technology Center, Lubbock, Texas 79416, United States.
J Am Chem Soc. 2017 Nov 8;139(44):15652-15655. doi: 10.1021/jacs.7b10328. Epub 2017 Oct 30.
Synthesis of giant unimolecular dendrimers is challenging due, in part, to difficulties encountered at higher generations, in both convergent and divergent protocols because of the multistep construction/purification process. Herein, we report a hybrid synthetic procedure in which the core is constructed last. This quantitative assembly generated a metallodendrimer that is supercharged (120+), large (11.3 nm diameter), and its core was previously established. The series of complexes has been unequivocally characterized by NMR, ESI-IM-MS, and TEM techniques.
由于多步构建/纯化过程，在收敛和发散方案中，在更高的代数中都会遇到困难，因此合成巨型单分子树状大分子具有挑战性。在此，我们报告了一种混合合成程序，其中最后构建核心。这种定量组装生成了一个超荷（120+）、大（11.3nm 直径）的金属树状大分子，其核心之前已经建立。通过 NMR、ESI-IM-MS 和 TEM 技术对该系列配合物进行了明确的表征。
