Redding McKenna J, Grayson Scott M, Charles Laurence
Department of Chemistry, Tulane University, New Orleans, Louisiana, USA.
Aix Marseille Université, CNRS, Institut de Chimie Radicalaire, Marseille, France.
Mass Spectrom Rev. 2025 Sep-Oct;44(5):682-714. doi: 10.1002/mas.21876. Epub 2024 Mar 19.
Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion-like structure. Owing to their chemical diversity, this review covers benefits of MS methods as a function of dendrimer classes, discussing advantages and limitations of ionization techniques, tandem mass spectrometry (MS/MS) strategies to determine the structure of defective species, as well as most recently demonstrated capabilities of ion mobility spectrometry (IMS) in the field. Complementarily, the well-defined structure of these macromolecules offers major advantages in the development of MS-based method, as reported in a second section reviewing uses of dendrimers as MS and IMS calibration standards and as multifunctional charge inversion reagents in gas phase ion/ion reactions.
质谱（MS）已成为表征树枝状大分子的一项重要技术，因为它在应对由其独特的洋葱状结构所带来的分析挑战方面已证明是有效的。由于树枝状大分子具有化学多样性，本综述涵盖了质谱方法作为树枝状大分子类别函数的优点，讨论了电离技术、用于确定缺陷物种结构的串联质谱（MS/MS）策略的优点和局限性，以及该领域中离子淌度谱（IMS）最近展示的能力。作为补充，这些大分子定义明确的结构在基于质谱的方法开发中具有主要优势，如在第二节中所报道的，该节回顾了树枝状大分子作为质谱和离子淌度谱校准标准以及作为气相离子/离子反应中的多功能电荷反转试剂的用途。
