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Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142.
Philos Trans R Soc Lond B Biol Sci. 1988 Dec 1;322(1208):155-7. doi: 10.1098/rstb.1988.0123.
The sex-determining region of the human Y chromosome contains a gene, ZFY, that encodes a zinc-finger protein. ZFY may prove to be the testis-determining factor. There is a closely related gene, ZFX, on the human X chromosome. In most species of placental mammals, we detect two ZFY-related loci: one on the Y chromosome and one on the X chromosome. However, there are four ZFY-homologous loci in mouse: Zfy-1 and Zfy-2 map to the sex-determining region of the mouse Y chromosome, Zfx is on the mouse X chromosome, and a fourth locus is autosomal.
人类Y染色体的性别决定区域包含一个名为ZFY的基因，该基因编码一种锌指蛋白。ZFY可能是睾丸决定因子。在人类X染色体上有一个与之密切相关的基因ZFX。在大多数胎盘哺乳动物物种中，我们检测到两个与ZFY相关的基因座：一个在Y染色体上，一个在X染色体上。然而，在小鼠中有四个与ZFY同源的基因座：Zfy-1和Zfy-2定位于小鼠Y染色体的性别决定区域，Zfx在小鼠X染色体上，还有一个基因座位于常染色体上。
