Mardon G, Mosher R, Disteche C M, Nishioka Y, McLaren A, Page D C
Whitehead Institute, Nine Cambridge Center, MA 02142.
Science. 1989 Jan 6;243(4887):78-80. doi: 10.1126/science.2563173.
The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.
人类Y染色体性别决定区域中的ZFY基因编码一种“锌指”蛋白，该蛋白可能是睾丸决定因子TDF。虽然大多数胎盘哺乳动物的Y染色体携带ZFY的单个同源物，但小鼠Y染色体有两个同源物，都位于性别决定（Sxr）区域。单独的Zfy-1可能足以决定雄性；Zfy-2是可有可无的，因为它在一个Sxr变体中被删除，该变体保留了性别决定功能，但失去了其他基因。两个基因座都定位在小鼠Y染色体的着丝粒附近。小家鼠和家鼠亚种的Y染色体可通过Zfy-1限制性片段多态性区分，这可用于研究它们与常染色体性别决定基因的不同相互作用。
