Nakano Tatsunori, Takahashi Masaharu, Takahashi Kazuaki, Nagashima Shigeo, Suzuki Yusuke, Nishigaki Yoichi, Tomita Eiichi, Okano Hiroshi, Oya Yumi, Shiraki Katsuya, Takase Kojiro, Sugimoto Kazushi, Koyama Junichi, Mizuo Hitoshi, Ikezawa Kazuto, Aikawa Tatsuya, Arai Masahiro, Okamoto Hiroaki
Department of Internal Medicine, Fujita Health University Nanakuri Memorial Hospital, Tsu, Mie 514-1295, Japan.
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329-0498, Japan.
Virology. 2018 Jan 1;513:146-152. doi: 10.1016/j.virol.2017.08.008. Epub 2017 Oct 24.
Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the origin and transmission route of the six HEV-3f strains. A time-scaled phylogenetic tree of the six strains with reference strains was constructed using a Bayesian statistical inference framework. The time-scaled tree indicated that the six strains independently derived from similar European strains between 2008 and 2014. The pattern suggested recent inflow of multiple HEV-3f strains from Europe to Japan. Japan imports a substantial amount of pork from European countries every year. The emergence of acute hepatitis cases caused by HEV-3f strains in Japan, in patients with no history of travel abroad, might be influenced by the increased opportunities to consume pork products imported from European countries.
戊型肝炎病毒3f亚型（HEV-3f）毒株通常在欧洲和泰国分离得到。最近，在日本的6例急性戊型肝炎患者中检测到了HEV-3f毒株，这些患者均无前往流行地区的旅行史。我们推断了这6株HEV-3f毒株的起源和传播途径。使用贝叶斯统计推断框架构建了这6株毒株与参考毒株的时间尺度系统发育树。时间尺度树表明，这6株毒株在2008年至2014年间独立源自相似的欧洲毒株。这种模式表明最近有多个HEV-3f毒株从欧洲流入日本。日本每年从欧洲国家进口大量猪肉。在无国外旅行史的患者中，日本出现由HEV-3f毒株引起的急性肝炎病例，可能受到食用从欧洲国家进口猪肉产品机会增加的影响。
