Inoue Izumi, Nakamura Fumiaki, Matsumoto Kimikazu, Takimoto Tetsuya, Higashi Takahiro
Division of Health Services Research, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.
Division of Health Services Research, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan; Division of Data Management, Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center, Osaka, Japan.
Cancer Epidemiol. 2017 Dec;51:74-80. doi: 10.1016/j.canep.2017.10.010. Epub 2017 Nov 5.
Adolescents and young adults (AYA) with cancer are confronted with unique challenges in areas of paramount concern within their age group, such as fertility, education, career, and delayed and long-term effects of treatment. However, the extent and depth of the problem has never been examined in the Japanese population. The aim of this study was to describe the status of cancer patients in the AYA population, using data from the hospital-based cancer registry (HBCR).
Patients included in the HBCR from January 2011 to December 2014 were included in this study to evaluate the incidence and cancer distribution trends among AYA. The total number and the proportion of AYA (15-39 years of age) stratified by sex, age, and cancer type were obtained. The incidence of age-specific cancer among AYA was also calculated.
We identified 30,394 male (35.1%) and 56,100 female (64.9%) cancer patients in the population, which collectively constituted about 3% of all invasive cancer cases. The incidence of cancer in AYA was estimated as 86.2 per 100,000 per year, and increased with age. The most affected population was women between 35 and 39 years of age (35%). Breast cancer was the most common type of cancer, followed by cervical, uterine, and thyroid cancers.
A substantial number of AYA are diagnosed with cancer every year. The distribution of cancer types in AYA was dependent on age and sex. These diversities in cancer types can inform researchers and policy makers to fine-tune their studies and policies.
患有癌症的青少年及青年（AYA）在其年龄组中极为关注的领域面临着独特的挑战，如生育、教育、职业以及治疗的延迟和长期影响。然而，该问题在日本人群中的严重程度和深度从未得到过研究。本研究的目的是利用基于医院的癌症登记处（HBCR）的数据来描述AYA人群中癌症患者的状况。
本研究纳入了2011年1月至2014年12月期间HBCR中的患者，以评估AYA中的发病率和癌症分布趋势。获取了按性别、年龄和癌症类型分层的AYA（15至39岁）的总数和比例。还计算了AYA中特定年龄癌症的发病率。
我们在该人群中确定了30394名男性（35.1%）和56100名女性（64.9%）癌症患者，他们共同构成了所有浸润性癌症病例的约3%。AYA中癌症的发病率估计为每年每10万人86.2例，并随年龄增长而增加。受影响最大的人群是35至39岁的女性（35%）。乳腺癌是最常见的癌症类型，其次是宫颈癌、子宫癌和甲状腺癌。
每年有大量AYA被诊断出患有癌症。AYA中癌症类型的分布取决于年龄和性别。这些癌症类型的差异可为研究人员和政策制定者提供信息，以微调他们的研究和政策。
