PAF1 复合物组成成分 Leo1 帮助将 Myc 募集到启动子处。
PAF1 complex component Leo1 helps recruit Myc to promoters.
机构信息
Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Zoological Institute, University of Zürich, 8057 Zürich, Switzerland.
出版信息
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9224-E9232. doi: 10.1073/pnas.1705816114. Epub 2017 Oct 16.
Abstract
The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
摘要
Myc 癌基因是一种转录因子，它对细胞生长和增殖具有强大的控制作用。Myc 与 E-box DNA 基序的物理相互作用已经得到了广泛的描述，但尚不清楚这种序列特异性相互作用是否足以使 Myc 与其转录靶标结合。在这里，我们确定了 PAF1 复合物，特别是其组成部分 Leo1，作为帮助 Myc 募集到靶基因的一个因子。由于 PAF1 复合物通常与活性基因相关联，因此与 Leo1 的这种相互作用有助于 Myc 靶向开放启动子。
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