Blasig I E, Loewe H, Ebert B
Academy of Sciences of the GDR, Inst. Drug. Res, Berlin.
Biomed Biochim Acta. 1988;47(10-11):S252-5.
The cardioprotective agents troxerutin and methionine are radical scavengers and compete with the DMPO adduct formation of .OH generated by the Fenton reaction. The concentration of trapped .O2- generated by the xanthine oxidase/hypoxanthine reaction is lowered in the presence of troxerutin. The decay of DMPO-OH is decreased by troxerutin compared to the control. In the presence of methionine a carbon-centered radical is produced. The investigations support the opinion that the scavenging of oxygen derived free radicals is of importance for the cardioprotective action of these agents.
具有心脏保护作用的药物曲克芦丁和蛋氨酸是自由基清除剂，它们能与芬顿反应产生的·OH形成的DMPO加合物竞争。在曲克芦丁存在的情况下，黄嘌呤氧化酶/次黄嘌呤反应产生的被捕获的·O2-浓度会降低。与对照组相比，曲克芦丁可降低DMPO-OH的衰减。在蛋氨酸存在的情况下会产生一个以碳为中心的自由基。这些研究支持了这样一种观点，即清除氧衍生的自由基对这些药物的心脏保护作用至关重要。
