Unit of Cardiac Physiology, Division of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, 3.18 Core Technology Facility, University of Manchester, 46 Grafton ST, Manchester M13 9NT, UK.
J Mol Cell Cardiol. 2018 Jan;114:364-368. doi: 10.1016/j.yjmcc.2017.10.009. Epub 2017 Oct 24.
There is great concern that results published in a large fraction of biomedical papers may not be reproducible. This article reviews the evidence for this and considers some of the factors that are responsible and how the problem may be solved. One issue is scientific fraud. This, in turn, may result from pressures put on scientists to succeed including the need to publish in "high impact" journals. I emphasise the importance of judging the quality of the science itself as opposed to using surrogate metrics. The other factors discussed include problems of experimental design and statistical analysis of the work. It is important that these issues are addressed by the scientific community before others impose draconian regulations.
人们非常担心，很大一部分生物医学论文的结果可能是不可重复的。本文回顾了这方面的证据，并考虑了一些导致这种情况的因素，以及如何解决这个问题。一个问题是科学欺诈。这反过来又可能是由于科学家成功的压力造成的，包括需要在“高影响力”期刊上发表论文。我强调了评判科学本身质量的重要性，而不是使用替代指标。讨论的其他因素包括实验设计和工作的统计分析问题。在其他方面强加严厉的规定之前，科学界解决这些问题是很重要的。
