Mortada Ibrahim, Mortada Rola
Independent Consultant, Beirut, Lebanon.
Independent Consultant, Beirut, Lebanon.
Eur J Med Genet. 2018 Feb;61(2):114-118. doi: 10.1016/j.ejmg.2017.10.015. Epub 2017 Oct 25.
Epigenetic factors are known to play a major role in determining stem cell fate and differentiation. Mesenchymal stem cells are the most studied population of stem cells due to their important applications in experimental biology and regenerative medicine. After a brief overview on mesenchymal stem cells, this review aims to highlight the role of epigenetic changes on mesenchymal stem cells biology and differentiation protocols with a focus on osteocytic, chondrocytic and adipocytic differentiation. Chromatin remodeling, DNA methylation, histone modifications and miRNA expression will be investigated. The impact of epigenetics on transdifferentiation of mesenchymal stem cells will also be discussed. Indeed, epigenetic modulation appears to constitute a promising experimental target in stem cell basic and translational research.
已知表观遗传因素在决定干细胞命运和分化方面发挥着重要作用。间充质干细胞因其在实验生物学和再生医学中的重要应用，是研究最多的干细胞群体。在对间充质干细胞进行简要概述之后本综述旨在强调表观遗传变化在间充质干细胞生物学和分化方案中的作用，重点关注骨细胞、软骨细胞和脂肪细胞的分化。将研究染色质重塑、DNA甲基化、组蛋白修饰和miRNA表达。还将讨论表观遗传学对间充质干细胞转分化的影响。事实上，表观遗传调控似乎构成了干细胞基础研究和转化研究中有前景的实验靶点。
