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表观遗传学与神经干细胞定向分化

Epigenetics and neural stem cell commitment.

作者信息

Tang Hai-Liang, Zhu Jian-Hong

机构信息

Department of Neurosurgery, Fudan University, Huashan Hospital; National Key Laboratory for Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

Neurosci Bull. 2007 Jul;23(4):241-8. doi: 10.1007/s12264-007-0036-8.

DOI:10.1007/s12264-007-0036-8
PMID:17687400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5550588/
Abstract

Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate.

摘要

神经干细胞是目前神经科学研究的热点。最近的进展表明，表观遗传调控与神经干细胞的自我更新和分化密切相关。表观遗传学是指对基因功能的有丝分裂/减数分裂遗传变化的研究，这些变化不能用DNA序列的变化来解释。主要的表观遗传机制包括DNA甲基化、组蛋白修饰、染色质重塑、基因组印记和非编码RNA。在这篇综述中，我们重点关注神经干细胞命运表观遗传机制的新见解。

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