Korelli A G, Davituliani D S
I. S. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Teilisi, USSR.
Acta Physiol Hung. 1988;72(3-4):307-13.
The effect of minor tranquilizers and neuroleptics was compared on self-stimulation and escape behaviourelicited by electrical stimulation of the hypothalamic nuclei in rabbits. It was shown that while tranquilizers (diazepam, oxazepam and meprobamate) increased the rate of self-stimulation elicited from the lateral hypothalamus, neuroleptics considerably suppressed such behaviour. Tranquilizers caused a remarkable reversal of the escape behaviour into a high-rate self-stimulation, both responses being induced from the same electrodes within the medial hypothalamus. Neuroleptics (chlorpromazine, reserpine and haloperidol) had not such an influence, though they somewhat increased the general activity of the animals. The reversing effect of the tranquilizers was compared with similar findings obtained after electrolytic ablation of the ventral hippocampus. It is suggested that the hippocampus has an inhibitory influence on the hypothalamic motivational system thus providing substantially for the animals' survival in a hostile environment.
比较了弱安定药和抗精神病药对家兔下丘脑核团电刺激诱发的自我刺激和逃避行为的影响。结果表明，安定药（地西泮、奥沙西泮和甲丙氨酯）可提高下丘脑外侧诱发的自我刺激速率，而抗精神病药则显著抑制这种行为。安定药可使逃避行为显著转变为高速率的自我刺激，这两种反应均由下丘脑内侧的同一电极诱发。抗精神病药（氯丙嗪、利血平和氟哌啶醇）没有这种影响，尽管它们在一定程度上增加了动物的总体活动。将安定药的逆转作用与腹侧海马电解损毁后获得的类似结果进行了比较。有人提出，海马对下丘脑动机系统具有抑制作用，从而在很大程度上确保动物在恶劣环境中的生存。
