Chromothripsis is linked to alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.
作者信息
Rücker Frank G, Dolnik Anna, Blätte Tamara J, Teleanu Veronica, Ernst Aurélie, Thol Felicitas, Heuser Michael, Ganser Arnold, Döhner Hartmut, Döhner Konstanze, Bullinger Lars
机构信息
Department of Internal Medicine III, University Hospital of Ulm, Albert-Einstein-Allee 23, Germany
Department of Internal Medicine III, University Hospital of Ulm, Albert-Einstein-Allee 23, Germany.
出版信息
Haematologica. 2018 Jan;103(1):e17-e20. doi: 10.3324/haematol.2017.180497. Epub 2017 Oct 27.
Abstract
摘要
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Chromothripsis is linked to alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.染色体碎裂与伴有复杂核型的急性髓系白血病中的改变、细胞周期损伤及不良预后相关。
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Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.成人急性髓系白血病的诊断与管理：2017年国际专家小组的欧洲白血病网络（ELN）建议
Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.
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Telomere dysfunction and chromothripsis.端粒功能障碍与染色体碎裂
Int J Cancer. 2016 Jun 15;138(12):2905-14. doi: 10.1002/ijc.30033. Epub 2016 Feb 29.
3
Chromothripsis and Kataegis Induced by Telomere Crisis.端粒危机引发的染色体碎裂和kataegis现象
Cell. 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054.
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Chromothripsis in cancer cells: An update.染色体重排（Chromothripsis）在癌细胞中的研究进展
Int J Cancer. 2016 May 15;138(10):2322-33. doi: 10.1002/ijc.29888. Epub 2015 Oct 30.
5
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome.端粒功能障碍会导致异常造血分化和骨髓增生异常综合征。
Cancer Cell. 2015 May 11;27(5):644-57. doi: 10.1016/j.ccell.2015.04.007.
6
Prevalence and clinical implications of chromothripsis in cancer genomes.癌症基因组中染色体重排的流行率及其临床意义。
Curr Opin Oncol. 2014 Jan;26(1):64-72. doi: 10.1097/CCO.0000000000000038.
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Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia.PML/RARα 和 PU.1 在急性早幼粒细胞白血病中对免疫蛋白酶体亚基的协调调控。
Oncogene. 2014 May 22;33(21):2700-8. doi: 10.1038/onc.2013.224. Epub 2013 Jun 17.
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Criteria for inference of chromothripsis in cancer genomes.癌症基因组中染色体碎裂推断的标准。
Cell. 2013 Mar 14;152(6):1226-36. doi: 10.1016/j.cell.2013.02.023.
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Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance.复杂核型急性髓细胞白血病中 miRNA 和基因表达的改变鉴定出具有预后相关性的网络。
Leukemia. 2013 Feb;27(2):353-61. doi: 10.1038/leu.2012.208. Epub 2012 Jul 19.
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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.对小儿髓母细胞瘤的基因组测序将灾难性的 DNA 重排与 TP53 突变联系起来。
Cell. 2012 Jan 20;148(1-2):59-71. doi: 10.1016/j.cell.2011.12.013.
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