• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Chromothripsis is linked to alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.

作者信息

Rücker Frank G, Dolnik Anna, Blätte Tamara J, Teleanu Veronica, Ernst Aurélie, Thol Felicitas, Heuser Michael, Ganser Arnold, Döhner Hartmut, Döhner Konstanze, Bullinger Lars

机构信息

Department of Internal Medicine III, University Hospital of Ulm, Albert-Einstein-Allee 23, Germany

Department of Internal Medicine III, University Hospital of Ulm, Albert-Einstein-Allee 23, Germany.

出版信息

Haematologica. 2018 Jan;103(1):e17-e20. doi: 10.3324/haematol.2017.180497. Epub 2017 Oct 27.

DOI:10.3324/haematol.2017.180497
PMID:29079594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5777208/
Abstract
摘要

相似文献

1
Chromothripsis is linked to alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.染色体碎裂与伴有复杂核型的急性髓系白血病中的改变、细胞周期损伤及不良预后相关。
Haematologica. 2018 Jan;103(1):e17-e20. doi: 10.3324/haematol.2017.180497. Epub 2017 Oct 27.
2
Chromothripsis in acute myeloid leukemia: biological features and impact on survival.急性髓系白血病中的染色体重排：生物学特征及其对生存的影响。
Leukemia. 2018 Jul;32(7):1609-1620. doi: 10.1038/s41375-018-0035-y. Epub 2018 Feb 23.
3
Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.标记染色体可由染色体重排产生，并可预测急性髓系白血病的不良预后。
Blood. 2017 Mar 9;129(10):1333-1342. doi: 10.1182/blood-2016-09-738161. Epub 2017 Jan 24.
4
Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple alterations.伴有多种改变的急性髓系白血病和骨髓增生异常综合征的单分子DNA测序
Haematologica. 2018 Jan;103(1):e13-e16. doi: 10.3324/haematol.2017.176719. Epub 2017 Oct 27.
5
Unique morphologic and genetic characteristics of acute myeloid leukemia with chromothripsis: a clinicopathologic study from a single institution.伴有染色体重排的急性髓系白血病的独特形态学和遗传学特征：来自单一机构的临床病理研究。
Hum Pathol. 2020 Apr;98:22-31. doi: 10.1016/j.humpath.2020.02.003. Epub 2020 Feb 21.
6
Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome.5q 缺失类型与急性髓系白血病和骨髓增生异常综合征中复杂核型、克隆进化、TP53 突变状态和预后的相关性。
Genes Chromosomes Cancer. 2014 May;53(5):402-10. doi: 10.1002/gcc.22151. Epub 2014 Feb 3.
7
The TP53 Pro72Arg SNP in de novo acute myeloid leukaemia - results of two cohort studies involving 215 patients and 3759 controls.初发急性髓系白血病中TP53 Pro72Arg单核苷酸多态性——两项涉及215例患者和3759例对照的队列研究结果
Br J Haematol. 2018 Apr;181(1):148-151. doi: 10.1111/bjh.14527. Epub 2017 Jan 20.
8
ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations.ERG 扩增是具有复杂核型和 TP53 突变的髓系恶性肿瘤中的继发复发性驱动事件。
Genes Chromosomes Cancer. 2022 Jul;61(7):399-411. doi: 10.1002/gcc.23027. Epub 2022 Feb 8.
9
Association between the TP53 Arg72Pro polymorphism and clinical outcomes in acute myeloid leukemia.TP53基因Arg72Pro多态性与急性髓系白血病临床结局的关联
Haematologica. 2017 Feb;102(2):e43-e46. doi: 10.3324/haematol.2016.155069. Epub 2016 Oct 20.
10
Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion.单倍体核型通常定义了急性髓系白血病中预后不良的亚组，并且经常与TP53缺失相关。
Leuk Lymphoma. 2012 Feb;53(2):336-7. doi: 10.3109/10428194.2011.608453. Epub 2011 Sep 19.

引用本文的文献

1
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.染色体碎裂相关的21号染色体扩增通过可靶向的DYRK1A过表达调控向急变期骨髓增殖性肿瘤的转化。
Nat Genet. 2025 Jun;57(6):1478-1492. doi: 10.1038/s41588-025-02190-6. Epub 2025 Jun 9.
2
Cancer cells' chamber of secrets: the link between micronuclei, chromothripsis and malignancy.癌细胞的秘密之室：微核、染色体碎裂与恶性肿瘤之间的联系
Open Biol. 2025 May;15(5):240388. doi: 10.1098/rsob.240388. Epub 2025 May 14.
3
TP53 -Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk-Stratification, and Management.TP53 突变的髓系肿瘤：2024 年诊断、风险分层及管理更新
Am J Hematol. 2025 Jun;100 Suppl 4(Suppl 4):88-115. doi: 10.1002/ajh.27655. Epub 2025 Mar 11.
4
From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy.从血液系统恶性肿瘤中p53的调控到去调控：对诊断、预后和治疗的影响
Biomark Res. 2024 Nov 14;12(1):137. doi: 10.1186/s40364-024-00676-9.
5
The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity.曲氟尿苷通过诱导异常有丝分裂产生的抗肿瘤作用不受调节p53活性的突变影响。
Cell Death Discov. 2024 Jul 2;10(1):307. doi: 10.1038/s41420-024-02083-3.
6
Chromothripsis in myeloid malignancies.染色体重排与髓系恶性肿瘤。
Ann Hematol. 2024 Oct;103(10):3955-3962. doi: 10.1007/s00277-024-05814-9. Epub 2024 May 30.
7
Chromothripsis is rare in IDH-mutant gliomas compared to IDH-wild-type glioblastomas whereas whole-genome duplication is equally frequent in both tumor types.与异柠檬酸脱氢酶（IDH）野生型胶质母细胞瘤相比，染色体碎裂在IDH突变型神经胶质瘤中较为罕见，而全基因组复制在这两种肿瘤类型中出现的频率相当。
Neurooncol Adv. 2024 Apr 18;6(1):vdae059. doi: 10.1093/noajnl/vdae059. eCollection 2024 Jan-Dec.
8
Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities.染色体重排：从异常有丝分裂到治疗机会的新兴十字路口。
J Mol Cell Biol. 2024 Sep 30;16(4). doi: 10.1093/jmcb/mjae016.
9
An Integrated Approach Including CRISPR/Cas9-Mediated Nanopore Sequencing, Mate Pair Sequencing, and Cytogenomic Methods to Characterize Complex Structural Rearrangements in Acute Myeloid Leukemia.一种综合方法，包括CRISPR/Cas9介导的纳米孔测序、配对末端测序和细胞基因组学方法，用于表征急性髓系白血病中的复杂结构重排。
Biomedicines. 2024 Mar 7;12(3):598. doi: 10.3390/biomedicines12030598.
10
Ring Chromosomes in Hematological Malignancies Are Associated with Gene Mutations and Characteristic Copy Number Variants.血液系统恶性肿瘤中的环状染色体与基因突变和特征性拷贝数变异相关。
Cancers (Basel). 2023 Nov 16;15(22):5439. doi: 10.3390/cancers15225439.

本文引用的文献

1
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.成人急性髓系白血病的诊断与管理：2017年国际专家小组的欧洲白血病网络（ELN）建议
Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.
2
Telomere dysfunction and chromothripsis.端粒功能障碍与染色体碎裂
Int J Cancer. 2016 Jun 15;138(12):2905-14. doi: 10.1002/ijc.30033. Epub 2016 Feb 29.
3
Chromothripsis and Kataegis Induced by Telomere Crisis.端粒危机引发的染色体碎裂和kataegis现象
Cell. 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054.
4
Chromothripsis in cancer cells: An update.染色体重排（Chromothripsis）在癌细胞中的研究进展
Int J Cancer. 2016 May 15;138(10):2322-33. doi: 10.1002/ijc.29888. Epub 2015 Oct 30.
5
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome.端粒功能障碍会导致异常造血分化和骨髓增生异常综合征。
Cancer Cell. 2015 May 11;27(5):644-57. doi: 10.1016/j.ccell.2015.04.007.
6
Prevalence and clinical implications of chromothripsis in cancer genomes.癌症基因组中染色体重排的流行率及其临床意义。
Curr Opin Oncol. 2014 Jan;26(1):64-72. doi: 10.1097/CCO.0000000000000038.
7
Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia.PML/RARα 和 PU.1 在急性早幼粒细胞白血病中对免疫蛋白酶体亚基的协调调控。
Oncogene. 2014 May 22;33(21):2700-8. doi: 10.1038/onc.2013.224. Epub 2013 Jun 17.
8
Criteria for inference of chromothripsis in cancer genomes.癌症基因组中染色体碎裂推断的标准。
Cell. 2013 Mar 14;152(6):1226-36. doi: 10.1016/j.cell.2013.02.023.
9
Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance.复杂核型急性髓细胞白血病中 miRNA 和基因表达的改变鉴定出具有预后相关性的网络。
Leukemia. 2013 Feb;27(2):353-61. doi: 10.1038/leu.2012.208. Epub 2012 Jul 19.
10
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.对小儿髓母细胞瘤的基因组测序将灾难性的 DNA 重排与 TP53 突变联系起来。
Cell. 2012 Jan 20;148(1-2):59-71. doi: 10.1016/j.cell.2011.12.013.