Porrino L J, Goodman N L, Sharpe L G
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Pharmacol Biochem Behav. 1988 Nov;31(3):623-6. doi: 10.1016/0091-3057(88)90240-7.
The reinforcing properties of amfonelic acid, a nonamphetamine psychostimulant, were evaluated in an intravenous self-administration paradigm. Rats were trained to self-administer cocaine (0.5-3.0 mg/kg/infusion) on a fixed-ratio 10 schedule of reinforcement via surgically implanted intravenous catheters during daily 4-hr sessions. Substitution of amfonelic acid (0.0625-0.250 mg/kg/infusion) reliably maintained self-administration in a dose-dependent manner. These data indicate that amfonelic acid can act as a reinforcer in rats, and further suggest that amfonelic acid may have abuse potential in humans.
在静脉注射自我给药范式中评估了非苯丙胺类精神兴奋剂安非尼酸的强化特性。通过手术植入的静脉导管，在每日4小时的实验时段内，训练大鼠按照固定比例10的强化程序自我给药可卡因（0.5 - 3.0毫克/千克/注射）。用安非尼酸（0.0625 - 0.250毫克/千克/注射）替代可卡因能以剂量依赖的方式可靠地维持自我给药行为。这些数据表明安非尼酸在大鼠中可作为强化物，进一步提示安非尼酸在人类中可能具有滥用潜力。
