Schechter M D
Pharmacol Biochem Behav. 1987 Feb;26(2):413-6. doi: 10.1016/0091-3057(87)90138-9.
Rats were trained to discriminate between the stimulus properties of intraperitoneally administered 0.8 mg/kg amfonelic acid and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance with lower amfonelic acid doses and analysis of the dose-response curve indicated an ED50 of 0.11 mg/kg. Administration of 0.08-0.6 mg/kg d-amphetamine produced a pattern of responding similar to that observed with amfonelic acid, with an ED50 of 0.10 mg/kg and a non-parallel dose-response curve. Likewise, the discriminative stimulus properties of amfonelic acid were shown to generalize to both d,l-cathinone and cocaine but not to apomorphine. The results suggest that amfonelic acid, as well as other non-amphetamine stimulants, acts by a different mechanism of action than does amphetamine and biochemical studies are reviewed to further evidence this observation.
在一项双杠杆、以食物为动机的操作性任务中，训练大鼠区分腹腔注射0.8毫克/千克安非他明酸及其溶媒的刺激特性。一旦训练完成，大鼠在较低剂量安非他明酸下的辨别性能呈现剂量相关下降，剂量-反应曲线分析表明半数有效剂量（ED50）为0.11毫克/千克。给予0.08 - 0.6毫克/千克的右旋苯丙胺产生了与安非他明酸相似的反应模式，半数有效剂量为0.10毫克/千克，且剂量-反应曲线不平行。同样，安非他明酸的辨别刺激特性被证明可泛化至消旋去甲伪麻黄碱和可卡因，但不能泛化至阿扑吗啡。结果表明，安非他明酸以及其他非苯丙胺类兴奋剂的作用机制与苯丙胺不同，本文回顾了生化研究以进一步证实这一观察结果。
