检查点抑制剂诱发的葡萄膜炎：病例系列
Checkpoint inhibitor-induced uveitis: a case series.
作者信息
Conrady Christopher D, Larochelle Marissa, Pecen Paula, Palestine Alan, Shakoor Akbar, Singh Ajay
机构信息
Department of Ophthalmology, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, 84112, USA.
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2018 Jan;256(1):187-191. doi: 10.1007/s00417-017-3835-2. Epub 2017 Oct 27.
PURPOSE
Checkpoint inhibitors are now a common treatment modality for metastatic cancer. In this manuscript, we describe the clinical features and management of autoimmune non-infectious uveitis induced by this class of drugs.
METHODS
Seven patients undergoing checkpoint inhibitor treatment for metastatic cancer from uveitis practices at three tertiary referral centers.
RESULTS
All seven patients developed various severities of ocular inflammatory disease while taking checkpoint inhibitors for metastatic disease.
CONCLUSIONS
Checkpoint inhibitors may induce autoimmune uveitis. Ocular complaints should prompt an early evaluation by an ophthalmologist.
目的
检查点抑制剂现已成为转移性癌症的常见治疗方式。在本手稿中，我们描述了这类药物诱发的自身免疫性非感染性葡萄膜炎的临床特征及管理。
方法
来自三个三级转诊中心葡萄膜炎诊疗科室的七名接受检查点抑制剂治疗转移性癌症的患者。
结果
所有七名患者在服用检查点抑制剂治疗转移性疾病期间均出现了不同程度的眼部炎症性疾病。
结论
检查点抑制剂可能诱发自身免疫性葡萄膜炎。眼部不适应促使眼科医生尽早进行评估。
Zotero 插件