Salo Silja A S, Ilonen Ilkka, Laaksonen Sanna, Myllärniemi Marjukka, Salo Jarmo A, Rantanen Tuomo
Department of Surgery, Institute of Clinical Medicine, University of Eastern Finland, Finland.
Department of Surgery, Clinicum, Faculty of Medicine, University of Helsinki, Finland; Department of General Thoracic and Esophageal Surgery, Heart and Lung Center, Helsinki University Hospital, Finland.
Cancer Epidemiol. 2017 Dec;51:81-86. doi: 10.1016/j.canep.2017.10.008. Epub 2017 Nov 5.
Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the mesothelial cells in the peritoneum with poor prognosis. Earlier reports from other countries indicate an incidence of 0.2-3 new cases per million per year. No previous studies have examined the national epidemiology of MPeM in Nordic countries. This study aimed to clarify the epidemiology of MPeM in Finland over a 12-year period.
The data consisted of cancer notifications, laboratory notifications, and death certificate information in the Finnish Cancer Registry (FCR) and Statistics Finland (SF) of all MPeM patients from 2000 to 2012 in Finland. We also collected data on occupational disease compensations from the Workers' Compensation Center (WCC) of Finland. Any missing information was collected from the respective patient's file of every patient obtained from health institutions that had treated the patients.
Between January 1, 2000 and December 31, 2012, 90 new MPeM cases (56 males, 34 females) occurred in Finland. Median annual incidence was four new cases, which corresponded to 0.74 new cases per million per year. MPeM was deemed an occupational disease in 21 patients (23.3%). 71 patients (78.9%) of whom had a known cause of death, with a median survival of 4 months. The number of deaths linked to other disease than mesothelioma was 28/74 (37.8%).
Our study indicates that MPeM in Finland is rare and fatal, which is in accordance with previous reports from other countries. MPeM is also a fatal disease, since most of the patients died due to MPeM.
恶性腹膜间皮瘤（MPeM）是一种罕见的腹膜间皮细胞癌，预后较差。其他国家早期报告显示每年每百万人口中有0.2 - 3例新发病例。此前尚无研究调查北欧国家MPeM的全国流行病学情况。本研究旨在阐明芬兰12年间MPeM的流行病学情况。
数据包括芬兰癌症登记处（FCR）和芬兰统计局（SF）中2000年至2012年芬兰所有MPeM患者的癌症通报、实验室通报及死亡证明信息。我们还从芬兰工人赔偿中心（WCC）收集了职业病赔偿数据。任何缺失信息均从治疗过患者的医疗机构获取的每位患者的相应病历中收集。
2000年1月1日至2012年12月31日期间，芬兰出现90例新的MPeM病例（56例男性，34例女性）。年发病率中位数为4例新病例，相当于每年每百万人口中有0.74例新病例。21例患者（23.3%）的MPeM被认定为职业病。71例患者（78.9%）有已知死亡原因，中位生存期为4个月。与间皮瘤以外其他疾病相关的死亡人数为28/74（37.8%）。
我们的研究表明，芬兰的MPeM罕见且致命，这与其他国家此前的报告一致。MPeM也是一种致命疾病，因为大多数患者死于MPeM。
