Hoffman D C, Beninger R J
Department of Psychology, Queen's University, Kingston, Canada.
Pharmacol Biochem Behav. 1988 Sep;31(1):1-8. doi: 10.1016/0091-3057(88)90302-4.
The neurotransmitter, dopamine (DA), has been implicated in place conditioning but the role of D1 and D2 receptors has not been investigated. In Experiment 1, the effects of SKF 38393 (0, 0.01, 0.1, 1.0, 10.0 mg/kg) and quinpirole (0, 0.01, 0.1, 1.0, 2.0, 4.0 mg/kg), preferential D1 and D2 receptor agonists, respectively, were evaluated and compared to (+)-amphetamine (0, 0.01, 0.1, 1.0, 2.0, 4.0 mg/kg). The experiment consisted of three phases. During the preexposure phase, rats explored two distinctive end compartments adjoined by a small tunnel. The time spent in each compartment was recorded. During the 8-day conditioning phase, rats were treated with drug and confined to one compartment for 30 min. On alternate days, rats received saline and were placed in the opposite compartment. Test days occurred over the remaining three days during which drug-free animals explored both compartments. Rats conditioned with (+)-amphetamine demonstrated a dose-dependent increase in time spent in the drug-paired environment from preexposure to test indicating the establishment of a conditioned place preference. Treatment with quinpirole also resulted in a conditioned place preference, however, only an intermediate dose was effective. In contrast, SKF 38393 produced a dose-dependent decrease in time spent on the drug-paired side suggesting the establishment of a place aversion. The idea that D1 receptors may be exclusively involved in mediating the aversive properties of psychomotor stimulants was tested in Experiment 2 employing a conditioned taste aversion paradigm. The results did not support this notion; it was found that both quinpirole and SKF 38393 produced a conditioned taste aversion.(ABSTRACT TRUNCATED AT 250 WORDS)
神经递质多巴胺（DA）已被证明与位置条件反射有关，但D1和D2受体在其中的作用尚未得到研究。在实验1中，分别评估了优先作用于D1和D2受体的激动剂SKF 38393（0、0.01、0.1、1.0、10.0 mg/kg）和喹吡罗（0、0.01、0.1、1.0、2.0、4.0 mg/kg）的效果，并与（+）-苯丙胺（0、0.01、0.1、1.0、2.0、4.0 mg/kg）进行比较。该实验包括三个阶段。在预暴露阶段，大鼠探索由一条小隧道相连的两个不同的末端隔室。记录在每个隔室中花费的时间。在为期8天的条件反射阶段，给大鼠注射药物并将其限制在一个隔室中30分钟。在交替的日子里，给大鼠注射生理盐水并将其放置在相对的隔室中。测试在接下来的三天进行，在此期间未用药的动物探索两个隔室。用（+）-苯丙胺进行条件反射的大鼠从预暴露到测试阶段，在药物配对环境中花费的时间呈剂量依赖性增加，表明建立了条件性位置偏好。用喹吡罗治疗也导致了条件性位置偏好，然而，只有中间剂量是有效的。相比之下，SKF 38393使在药物配对一侧花费的时间呈剂量依赖性减少，表明建立了位置厌恶。在实验2中，采用条件性味觉厌恶范式测试了D1受体可能专门参与介导精神运动兴奋剂厌恶特性的观点。结果不支持这一观点；发现喹吡罗和SKF 38393都产生了条件性味觉厌恶。（摘要截短至250字）
