Harris J C, Newman J D
Division of Child Psychiatry, Johns Hopkins University, Baltimore, MD 21205.
Pharmacol Biochem Behav. 1988 Sep;31(1):223-6. doi: 10.1016/0091-3057(88)90337-1.
This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the alpha 2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.
本研究为阿片类和去甲肾上腺素能神经元系统对灵长类动物发声行为的相互作用提供了证据。成年松鼠猴发出啁啾声的速率通过联合给予α2肾上腺素能拮抗剂育亨宾和阿片类拮抗剂纳洛酮以相加或协同的方式增加。在隔离叫声上未显示出类似效果。此外，药物组合导致自主症状增加。这些发现的解剖学定位以及产生啁啾声增加的机制需要进一步研究。
