Charney D S, Heninger G R
Arch Gen Psychiatry. 1986 Nov;43(11):1037-41. doi: 10.1001/archpsyc.1986.01800110023004.
To evaluate interactions between the opiate and adrenergic systems in healthy humans, concomitant administration of the opiate antagonist, naloxone hydrochloride, and the alpha 2-adrenergic receptor antagonist, yohimbine hydrochloride, was compared with the administration of placebo and of each drug separately. A synergistic effect of the combination (larger than the sum of the effects of the two drugs separately) was observed on subject ratings of nervousness, anxiety, tremors, palpitations, nausea, hot and cold flashes, and increased plasma cortisol concentrations. In addition, following the combination, each of the male subjects studied reported a full penile erection lasting at least 60 minutes, an effect not reported when each drug was given separately. These results demonstrate that interactions between the opiate the adrenergic systems have important implications for our understanding of the cause and treatment of anxiety disorders and male impotence.
为评估健康人体内阿片类系统与肾上腺素能系统之间的相互作用，将阿片类拮抗剂盐酸纳洛酮和α2-肾上腺素能受体拮抗剂盐酸育亨宾联合给药的效果，与安慰剂及单独使用每种药物的效果进行了比较。在紧张、焦虑、震颤、心悸、恶心、潮热和寒战等主观评分以及血浆皮质醇浓度升高方面，观察到联合用药具有协同效应（大于两种药物单独使用时效应之和）。此外，联合用药后，参与研究的每位男性受试者均报告有持续至少60分钟的完全阴茎勃起，而单独使用每种药物时未报告有此效应。这些结果表明，阿片类系统与肾上腺素能系统之间的相互作用对于我们理解焦虑症和男性阳痿的病因及治疗具有重要意义。
