当前争议：游离维生素代谢物水平是否比总水平更能准确评估维生素 D 状况？
Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?
机构信息
Department of Medicine, University of California San Francisco, San Francisco VA Medical Center, 1700 Owens Street, San Francisco, CA 94158, USA.
University of California San Francisco, 1700 Owens Street, San Francisco, CA 94158, USA; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Endocrinol Metab Clin North Am. 2017 Dec;46(4):901-918. doi: 10.1016/j.ecl.2017.07.013.
Abstract
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert their biologic effects. For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively). Assays to measure the free vitamin D metabolite levels have been developed, and initial studies indicated their value in subjects with altered DBP levels.
摘要
游离激素假说认为，只有非结合部分（游离部分）的激素能够进入细胞并发挥其生物学效应，而这些激素在血液中通常与载体蛋白结合。对于维生素 D 代谢物，小于 1%（1,25(OH)D 为 0.4%，25(OH)D 为 0.03%）是游离的，超过 99%与维生素 D 结合蛋白（DBP）和白蛋白结合（分别约为 85%和 15%）。已经开发出测量游离维生素 D 代谢物水平的检测方法，初步研究表明它们在 DBP 水平改变的受试者中有价值。
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