Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States.
Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States.
Neurochem Int. 2018 Jan;112:1-4. doi: 10.1016/j.neuint.2017.10.011. Epub 2017 Oct 26.
We report a significant reduction in plasma methionine concentrations in relapse remitting multiple sclerosis (MS) patients compared to controls. In vivo studies demonstrate that changes in peripheral methionine levels in mice can regulate histone H3 methylation and expression of DNA methyltransferase 3A (DNMT3A) centrally, in the cerebral cortex. Therefore, we propose that decreases in circulating methionine represent one of the earliest manifestations of dysregulated methionine metabolism in MS with potential impacts on both histone H3 and DNA methylation in the central nervous system.
我们报告称，与对照组相比，复发缓解型多发性硬化症（MS）患者的血浆蛋氨酸浓度显著降低。体内研究表明，在小鼠中，外周蛋氨酸水平的变化可以在中枢（大脑皮层）调节组蛋白 H3 甲基化和 DNA 甲基转移酶 3A（DNMT3A）的表达。因此，我们提出，循环蛋氨酸的减少代表了 MS 中蛋氨酸代谢失调的最早表现之一，这可能对中枢神经系统中的组蛋白 H3 和 DNA 甲基化都有影响。
