Resident of Pharmacology, Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Regul Toxicol Pharmacol. 2017 Dec;91:159-164. doi: 10.1016/j.yrtph.2017.10.025. Epub 2017 Nov 6.
Auraptene (AUR) is a natural, bioactive, monoterpene coumarin ether. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective properties. The aim of the present study was to assess the acute and subacute toxicity of oral administration of AUR in rats by evaluating clinical signs, haematology, biochemical factors, pathological changes and immune-toxicity. Acute administration of AUR in doses of 125, 250, 500, 1000 and 2000 mg/kg body weight had no mortality or clinical signs in a period of two days. To evaluate subacute toxicity, AUR was administrated for 28 days by oral gavage in doses of 125 and 250 mg/kg. There were significant differences in the haematological and biochemical data of the treated and untreated groups. However, almost all haematological differences were within normal reference ranges. Subacute administration of AUR showed no toxic histopathological effects on organ tissue. Evaluation of immune-toxicity also revealed no significant differences between treatment and untreated groups.
佛手柑内酯（AUR）是一种天然的、具有生物活性的单萜香豆素醚。它具有抗炎、抗癌、抗菌、神经保护和保肝作用。本研究的目的是通过评估临床症状、血液学、生化因素、组织病理学变化和免疫毒性，来评估 AUR 在大鼠体内经口给药的急性和亚急性毒性。在两天的时间内，以 125、250、500、1000 和 2000mg/kg 体重的剂量给予 AUR 急性给药，没有死亡率或临床症状。为了评估亚急性毒性，以 125 和 250mg/kg 的剂量通过口服灌胃给予 AUR 28 天。在处理组和未处理组之间的血液学和生化数据存在显著差异。然而，几乎所有的血液学差异都在正常参考范围内。AUR 的亚急性给药对器官组织没有显示出有毒的组织病理学影响。免疫毒性的评估也显示，治疗组和未治疗组之间没有显著差异。
