Cerri C, Canal N, Frattola L
J Neurol Neurosurg Psychiatry. 1978 Sep;41(9):805-8. doi: 10.1136/jnnp.41.9.805.
Guanylate cyclase activity has been studied in muscle of normal subjects and of patients suffering from muscular and neuromuscular diseases. In normal tissue a guanylate cyclase activity was found in both soluble and particulate fractions of homogenate. We found also that the kinetic analysis of the enzyme of soluble differed from that of particulate fraction. A decrease of guanylate cyclase activity in crude homogenate was observed in muscular dystrophies, in neuromuscular atrophies, and in inflammatory forms of muscle disease.
已对正常受试者以及患有肌肉和神经肌肉疾病的患者的肌肉中的鸟苷酸环化酶活性进行了研究。在正常组织中，在匀浆的可溶性和颗粒性部分均发现了鸟苷酸环化酶活性。我们还发现，可溶性部分的酶的动力学分析与颗粒性部分的不同。在肌肉营养不良、神经肌肉萎缩以及肌肉疾病的炎症形式中，观察到粗匀浆中鸟苷酸环化酶活性降低。
