Xie G Y, Chen W, Wang Q K, Cheng X R, Xu J N, Huang P L
National Insititue of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017 Jul 20;35(7):487-490. doi: 10.3760/cma.j.issn.1001-9391.2017.07.003.
To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice. 40 ICR mice were randomly divided into 5 groups: one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0、0.5、5.0、50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexes、hematology indexes, the activities of SOD、GSH-Px and the concentration of MDA were all detected. The results showed in the four CdTe QDs exposure groups, the level of CRE、PLT and the concentration of MDA were all significantly lower than those of the control group (<0.05 or <0.01) ; the activities GSHPx in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group (<0.01) . It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in mice.
为研究碲化镉量子点（QDs）对小鼠的氧化损伤作用。将40只ICR小鼠随机分为5组：1个对照组（生理盐水）；4个碲化镉量子点组（分别通过静脉注射0.2 ml浓度为0、0.5、5.0、50.0和500.0 nmol/ml的碲化镉量子点进行暴露）。24小时后，将小鼠断头取血，检测血清生化指标、血液学指标、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）浓度。结果显示，在4个碲化镉量子点暴露组中，肌酐（CRE）、血小板（PLT）水平及MDA浓度均显著低于对照组（<0.05或<0.01）；50.0和500.0 nmol/ml碲化镉量子点组的GSH-Px活性显著高于对照组（<0.01）。提示0.5 nmol/ml的碲化镉量子点可诱导小鼠产生氧化损伤作用。
