Usta Akin, Turan Gulay, Adali Ertan
Department of Obstetrics and Gynecology, School of Medicine, Balikesir Univesity.
Laboratory of Pathology, Balikesir Ataturk State Hospital.
Tohoku J Exp Med. 2017 Oct;243(2):141-150. doi: 10.1620/tjem.243.141.
Endometriosis is defined as the presence of functional endometrial tissues outside of the uterine cavity. Ovarian endometrioma is the most common type of endometriosis. It is an estrogen-dependent inflammatory disease that frequently causes infertility and chronic pelvic pain. Cyclophilin A (CyPA) is secreted from various types of cells in response to inflammatory stimuli. Many previous studies have shown that the increased expression and/or heightened plasma levels of CyPA exacerbates inflammation. The aim of this study is to evaluate CyPA immunoreactivity in ovarian endometrioma cyst wall. In this cross-sectional study, CyPA immunoreactivity in endometrial tissue samples obtained from uterine cavity and in endometrioma cyst walls of 44 consecutive women with ovarian endometrioma were compared with control endometrial tissue samples obtained from uterine cavity of 40 women without endometrioma. All endometrioma samples were confirmed via histopathological examination. Finally, the relationship between CyPA immunoreactivity and the clinicopathological findings related to endometrioma were evaluated. The CyPA expression rates in glandular cells, stromal cells, and the capillary endothelium were significantly higher in endometrioma cyst walls of women with ovarian endometrioma than in the control endometrial tissue of women without endometrioma (p = 0.0002, p = 0.0417 and p = 0.0067, respectively). The correlation analysis demonstrated that glandular CyPA expression was correlated with endometrioma recurrence (p = 0.0267). However, stromal and vascular endothelial CyPA expression were correlated with dysmenorrhea recurrence (p = 0.0023 and p = 0.0003, respectively). In conclusion, the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.
子宫内膜异位症的定义是子宫腔外存在功能性子宫内膜组织。卵巢子宫内膜异位囊肿是子宫内膜异位症最常见的类型。它是一种雌激素依赖性炎症性疾病，常导致不孕和慢性盆腔疼痛。亲环素A（CyPA）由各种类型的细胞在炎症刺激下分泌。许多先前的研究表明，CyPA表达增加和/或血浆水平升高会加剧炎症。本研究的目的是评估CyPA在卵巢子宫内膜异位囊肿壁中的免疫反应性。在这项横断面研究中，将44例连续患有卵巢子宫内膜异位囊肿的女性的子宫内膜组织样本以及子宫内膜异位囊肿壁中的CyPA免疫反应性与40例无子宫内膜异位症女性的子宫腔获得的对照子宫内膜组织样本进行了比较。所有子宫内膜异位囊肿样本均通过组织病理学检查得到证实。最后，评估了CyPA免疫反应性与子宫内膜异位囊肿相关临床病理结果之间的关系。患有卵巢子宫内膜异位囊肿的女性的子宫内膜异位囊肿壁中的腺细胞、基质细胞和毛细血管内皮中的CyPA表达率显著高于无子宫内膜异位症女性的对照子宫内膜组织（分别为p = 0.0002、p = 0.0417和p = 0.0067）。相关性分析表明，腺细胞CyPA表达与子宫内膜异位囊肿复发相关（p = 0.0267）。然而，基质细胞和血管内皮CyPA表达与痛经复发相关（分别为p = 0.0023和p = 0.0003）。总之，异位子宫内膜组织中CyPA表达增加与子宫内膜异位囊肿复发和血管生成有关。
