Department of Ophthalmology, Balikesir Ataturk City Hospital, Balikesir, Turkey.
Faculty of Medicine, Department of Pathology, Balıkesir University, Balıkesir, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2020 Apr;258(4):931-937. doi: 10.1007/s00417-019-04591-w. Epub 2020 Jan 2.
The aim of this study was to investigate the effect of endometriosis on the ocular surface.
A total of 50 patients were included in the study and divided into two groups. Group 1 consisted of 25 patients with endometriosis. Group 2 had 25 control patients. All patients underwent complete ophthalmic examination, and the right eyes were included in the study. To evaluate the ocular surface, both groups were tested with the following: the Schirmer I test, tear breakup time (TBUT), the conjunctival impression cytology (CIC), and the Ocular Surface Disease Index (OSDI). The results were subsequently compared.
The average Schirmer I test results were 8.40 ± 2.74 mm in group 1 and were significantly lower in patients with endometriosis (P < 0.001). The average TBUT test results were 9.04 ± 3.61 s in group 1 and were significantly lower in patients with endometriosis (P < 0.001). The average OSDI results were 24.04 ± 9.29 in group 1 and were significantly higher in patients with endometriosis (P < 0.001). The average CIC results were 1.76 ± 0.88 in group 1 and were significantly higher in patients with endometriosis (P < 0.001).
Ocular surface changes, including squamous metaplasia, may be observed in the conjunctiva of patients with endometriosis.
本研究旨在探讨子宫内膜异位症对眼表的影响。
本研究纳入了 50 名患者，分为两组。第 1 组 25 例患者患有子宫内膜异位症，第 2 组 25 例为对照组患者。所有患者均接受了全面的眼科检查，右眼纳入研究。为评估眼表，两组均进行了以下检查：Schirmer I 试验、泪膜破裂时间（TBUT）、结膜印迹细胞学（CIC）和眼表疾病指数（OSDI）。随后比较了结果。
第 1 组的平均 Schirmer I 试验结果为 8.40±2.74mm，子宫内膜异位症患者的结果明显更低（P<0.001）。第 1 组的平均 TBUT 试验结果为 9.04±3.61s，子宫内膜异位症患者的结果明显更低（P<0.001）。第 1 组的平均 OSDI 结果为 24.04±9.29，子宫内膜异位症患者的结果明显更高（P<0.001）。第 1 组的平均 CIC 结果为 1.76±0.88，子宫内膜异位症患者的结果明显更高（P<0.001）。
子宫内膜异位症患者的结膜可能出现鳞状化生等眼表变化。
