Vergunst Annette C, Carranza Nazareth Lopez, Zhang Lili, Gomes Margarida C, Tasrini Yara, Meijer Annemarie H, O'Callaghan David
VBMI, INSERM, Univ. Montpellier, Nîmes, France.
Current address: Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, USA.
Microb Cell. 2017 Sep 13;4(10):362-364. doi: 10.15698/mic2017.10.595.
Opportunistic pathogens are a worldwide cause of mortality and morbidity, and infections with intrinsically antibiotic-resistant pathogens have a large clinical, social and economic impact. Bacteria belonging to the complex (Bcc), ubiquitous in natural and industrial environments, are notorious pathogens for individuals with cystic fibrosis (CF). In addition, is emerging as the culprit of non-CF related, sometimes fatal infections. Knowledge of the underlying infection mechanism of these pathogens is important for efficient treatment, however, to date not much is known about the lifestyle of Bcc bacteria during infection. In our recent study published in PLoS Pathogens, we provide experimental evidence that macrophages are critically important for proliferation of , and are major drivers of fatal pro-inflammatory infections in zebrafish larvae. This is in agreement with recent clinical information showing that is mainly localised in phagocytes in infected CF lungs. A predominant intramacrophage stage and a host-detrimental role for macrophages have major implications for treatment strategies of both CF and non-CF infections. Intracellular survival of bacteria traditionally classified as extracellular, including and , is an emerging theme. Our finding that macrophages are essential for proliferation of in the host suggests a new paradigm for Bcc infections and urges the development of novel anti-infectious therapies to efficiently disarm these intrinsically antibiotic resistant facultative intracellular pathogens.
机会性病原体是全球范围内导致死亡和发病的原因，而感染具有内在抗生素耐药性的病原体具有重大的临床、社会和经济影响。属于该菌群（Bcc）的细菌在自然和工业环境中普遍存在，是囊性纤维化（CF）患者臭名昭著的病原体。此外，该菌群正成为非CF相关感染（有时是致命感染）的罪魁祸首。了解这些病原体的潜在感染机制对于有效治疗很重要，然而，迄今为止，对于Bcc细菌在感染期间的生活方式知之甚少。在我们最近发表在《公共科学图书馆·病原体》上的研究中，我们提供了实验证据，表明巨噬细胞对于该菌群的增殖至关重要，并且是斑马鱼幼虫致命性促炎性感染的主要驱动因素。这与最近的临床信息一致，该信息表明该菌群主要定位于感染的CF肺部的吞噬细胞中。巨噬细胞中该菌群占主导地位的阶段以及巨噬细胞对宿主有害的作用对CF和非CF感染的治疗策略都具有重大意义。传统上归类为胞外菌的细菌（包括该菌群和其他细菌）的细胞内存活是一个新出现的主题。我们发现巨噬细胞对于该菌群在宿主体内的增殖至关重要，这为Bcc感染提出了一个新的范例，并促使开发新的抗感染疗法，以有效地消除这些具有内在抗生素耐药性的兼性胞内病原体。
