Ji HaYeun, Kim Hye Sung, Kim Hae-Won, Leong Kam W
Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, South Korea.
Curr Opin Biomed Eng. 2017 Mar;1:38-44. doi: 10.1016/j.cobme.2017.02.005. Epub 2017 Mar 22.
Vascular smooth muscle cells (SMC) play an essential role in remodeling the vasculature during disease progression. Induced pluripotent stem cells (iPSC) provide an attractive approach to obtain autologous SMC source for patient-specific disease modeling. Here we discuss the current methods to 1) derive functional SMC from iPSC, 2) model vascular diseases using SMC generated from patient-derived iPSC, and 3) modulate microenvironmental cues to enhance cellular differentiation and functionality and better mimic the physiological environment. We emphasize that continuous exploration of biomaterial technologies to engineer a more SMC-specific microenvironment will provide further insight on complex vascular diseases.
血管平滑肌细胞（SMC）在疾病进展过程中对血管重塑起着至关重要的作用。诱导多能干细胞（iPSC）为获取用于患者特异性疾病建模的自体SMC来源提供了一种有吸引力的方法。在这里，我们讨论当前的方法，即1）从iPSC中衍生出功能性SMC，2）使用从患者来源的iPSC生成的SMC对血管疾病进行建模，以及3）调节微环境线索以增强细胞分化和功能，并更好地模拟生理环境。我们强调，持续探索生物材料技术以构建更具SMC特异性的微环境将为复杂血管疾病提供进一步的见解。
