Little Bert B, Ignasiak Zofia, Sławinska Teresa, Posłuszny Pawel, Malina R M, Wiegman David L
a School of Public Health and Information Sciences , University of Louisville , Louisville , KY , USA.
b Department of Anthropology , University of Louisville , Louisville , KY , USA.
Ann Hum Biol. 2017 Dec;44(8):723-728. doi: 10.1080/03014460.2017.1387284. Epub 2017 Oct 30.
Reduced vital capacity (VC) and forced vital capacity (FVC) are associated with lead (Pb) exposure.
The objective of this study is to analyse the effects of Pb on FVC and the shuttle run performance.
Data were available for 184 male and 189 female Polish schoolchildren aged 10-15 years. Regression analysis was performed of shuttle run performance (dependent) on Pb and FVC.
Shuttle run time increased by 1.75 (± 0.77) and 1.97 (± 0.77) seconds for each 10 µg/dL increase in Pb blood among males and females, respectively. Higher shuttle run times indicate poorer performance. Average unadjusted blood Pb level in the sample was 5.27 μg/dL (± 0.19 SE) and 3.82 μg/dL (± 0.10 SE), respectively. Path analysis was used to assess the association of Pb level with shuttle run time. Blood Pb had a significant negative effect on VC (B= -13.60 ± 3.28 [SE], p < 0.0001) and FVC (B = -13.08 ± 3.27, p < 0.0001). FVC had a small but significant effect on shuttle run time (B = -0.04 ± 0.007, p < 0.0001). Pb had a significant effect on the residual of shuttle run time among males (B = 1.59 ± 0.75, p < 0.03) and females after the effect of FVC was removed (B = 1.49 ± 0.73, p < 0.04).
Thus, Pb had direct and indirect effects that increased shuttle run time, i.e. negatively affected performance.
肺活量（VC）和用力肺活量（FVC）降低与铅（Pb）暴露有关。
本研究的目的是分析铅对FVC和往返跑成绩的影响。
研究数据来自184名年龄在10至15岁的波兰男学生和189名年龄在10至15岁的波兰女学生。对往返跑成绩（因变量）与铅和FVC进行回归分析。
男性和女性血铅水平每升高10μg/dL，往返跑时间分别增加1.75（±0.77）秒和1.97（±0.77）秒。往返跑时间越长表明成绩越差。样本中未经调整的平均血铅水平分别为5.27μg/dL（±0.19标准误）和3.82μg/dL（±0.10标准误）。采用路径分析评估血铅水平与往返跑时间的关联。血铅对VC（B = -13.60 ± 3.28[标准误]，p < 0.0001）和FVC（B = -13.08 ± 3.27，p < 0.0001）有显著负面影响。FVC对往返跑时间有微小但显著的影响（B = -0.04 ± 0.007，p < 0.0001）。在去除FVC的影响后，铅对男性（B = 1.59 ± 0.75，p < 0.03）和女性往返跑时间的残差有显著影响（B = 1.49 ± 0.73，p < 0.04）。
因此，铅具有直接和间接影响，增加了往返跑时间，即对成绩产生负面影响。
