β受体阻滞剂、脂蛋白与非胰岛素依赖型糖尿病
Beta-blockers, lipoproteins and non-insulin dependent diabetes.
作者信息
Feher M D, Rains S G, Richmond W, Torrens D, Wilson G, Wadsworth J, Sever P S, Elkeles R S
机构信息
Department of Clinical Pharmacology, St. Mary's Hospital, London, UK.
出版信息
Postgrad Med J. 1988 Dec;64(758):926-30. doi: 10.1136/pgmj.64.758.926.
In a study on 138 hypertensive non-insulin dependent diabetic subjects, factors influencing lipoproteins were assessed. Multiple regression analyses were carried out in order to assess the influence of beta-blocker antihypertensive therapy while making allowances for other confounding variables. In males, but not in females, on a beta-blocker for hypertension, total high density lipoprotein- (HDL-) and HDL-subfraction cholesterol were significantly lower while the serum triglyceride was increased, though not significantly. In male non-insulin dependent diabetics, regimens containing a beta-blocker may worsen an already abnormal lipoprotein profile and antihypertensive agents other than beta-blocking agents should be used if possible.
在一项针对138名高血压非胰岛素依赖型糖尿病患者的研究中，对影响脂蛋白的因素进行了评估。进行了多元回归分析，以评估β受体阻滞剂抗高血压治疗的影响，同时考虑其他混杂变量。在男性中，而非女性中，接受β受体阻滞剂治疗高血压时，总高密度脂蛋白（HDL）和HDL亚组分胆固醇显著降低，而血清甘油三酯虽未显著升高但有所增加。在男性非胰岛素依赖型糖尿病患者中，包含β受体阻滞剂的治疗方案可能会使本已异常的脂蛋白谱恶化，如有可能应使用β受体阻滞剂以外的抗高血压药物。
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