Tworek Damian, Antczak Adam
Department of General and Oncological Pulmonology, Medical University of Lodz, Poland.
Adv Respir Med. 2017;85(5):271-276. doi: 10.5603/ARM.a2017.0045. Epub 2017 Oct 30.
Chronic Obstructive Pulmonary Disease (COPD) has been traditionally associated with neutrophilic inflammation of the bronchi. Studies from the early 1990s demonstrated that eosinophils may also get into the lower airways of patients with COPD and their increased numbers can be noticed during exacerbations as well as stable disease. Eosinophilic phenotype of COPD is characterized by several unique features, i.e. a specific pattern of airway inflammation and distinct clinical course or susceptibility to corticosteroid treatment. In this paper, we present an up-to-date review of the literature on clinical characteristics of eosinophilic COPD, as well as the role of eosinophils as a biomarker-guided therapy in COPD.
慢性阻塞性肺疾病（COPD）传统上一直与支气管的嗜中性粒细胞炎症相关。20世纪90年代初的研究表明，嗜酸性粒细胞也可能进入COPD患者的下呼吸道，并且在病情加重期以及病情稳定期都可以观察到其数量增加。COPD的嗜酸性粒细胞表型具有几个独特特征，即气道炎症的特定模式、独特的临床病程或对皮质类固醇治疗的易感性。在本文中，我们对嗜酸性粒细胞性COPD的临床特征以及嗜酸性粒细胞作为COPD生物标志物指导治疗的作用的文献进行了最新综述。
