State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
College of Chemistry & Environmental Science, HeBei University , 180 Wusi Donglu, Baoding 071002, People's Republic of China.
J Org Chem. 2017 Dec 1;82(23):12386-12394. doi: 10.1021/acs.joc.7b02196. Epub 2017 Nov 8.
An efficient palladium-catalyzed dearomatizing [2+2+1] carbocyclization of 1,7-enynes with iodophenols has been developed. A type of tetracyclic scaffold was built in this reaction, exhibiting a broad substrate scope with moderate to excellent yields. More importantly, this method provides a potential strategy for the synthesis of tetracyclic skeleton natural products.
一种高效的钯催化 1,7-烯炔与碘苯酚的去芳构化[2+2+1]碳环化反应已经被开发出来。在这个反应中构建了一种四环支架，表现出广泛的底物范围，中等至优异的产率。更重要的是，这种方法为四环骨架天然产物的合成提供了一种潜在的策略。
