Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering , Inner Mongolia University , Hohhot 010021 , People's Republic of China.
J Org Chem. 2018 Nov 16;83(22):14181-14194. doi: 10.1021/acs.joc.8b02363. Epub 2018 Nov 1.
A novel palladium-catalyzed cascade carbopalladation/phenol dearomatization reaction has been achieved. The process provides a variety of indolone-, dihydrobenzofuran-, dihydrobenzopyran- and hydroquinoline-containing spirofused molecules bearing two quaternary centers in moderate to good yields. The potential synthetic utility of this method is demonstrated by a gram-scale experiment and further transformations.
一种新型钯催化的级联碳钯化/酚去芳构化反应已经实现。该过程以中等至良好的收率提供了多种含有吲哚酮、二氢苯并呋喃、二氢苯并吡喃和氢醌的螺稠合分子，带有两个季碳原子。通过克级实验和进一步的转化证明了该方法的潜在合成用途。
