Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Chemistry Department, Faculty of Science, Sohag University , Sohag 82524, Egypt.
Org Lett. 2017 Nov 17;19(22):6176-6179. doi: 10.1021/acs.orglett.7b03094. Epub 2017 Oct 30.
An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8-11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope.
一种基于 Ugi 多组分反应的两步策略被应用于中环的合成。在第一步线性扩张阶段,一系列二胺与环酐反应,生成不同长度的末端合成氨基酸作为第二步的起始原料。Ugi-4-中心 3-组分反应被用于通过异氰化物和羰基化合物的添加构建复杂的中环(8-11)。该方法具有条件温和、底物范围广泛的特点。