Gasińska T, Drózdz M, Izbicka M, Szydło E
Endokrynol Pol. 1988;39(6):327-37.
The study was aimed at evaluation of the effect of short-term treatment with one of the six beta adrenolytic drugs (propranolol, metoprolol, atenolol, pindolol, nadolol, acebutolol) and calcium antagonist nifedipine on the values of several parameters of calcium-phosphorus metabolism in 81 patients with hyperthyroidism (14 patients with Graves' disease, and 67 patients with toxic nodular goiter), and 82 patients with simple goiter. The patients studied have been divided into seven groups, each receiving one of the investigated drugs during four days. A significant decrease in the urinary excretion of hydroxyproline was found only in the patients with hyperthyroidism receiving propranolol. This effect of propranolol on hydroxyprolinuria was not related to the degree of lowering of serum T3 concentration observed in these patients.
该研究旨在评估六种β-肾上腺素能阻滞剂（普萘洛尔、美托洛尔、阿替洛尔、吲哚洛尔、纳多洛尔、醋丁洛尔）之一及钙拮抗剂硝苯地平对81例甲状腺功能亢进患者（14例格雷夫斯病患者和67例毒性结节性甲状腺肿患者）以及82例单纯性甲状腺肿患者钙磷代谢若干参数值的短期治疗效果。所研究的患者被分为七组，每组在四天内接受一种被研究药物。仅在接受普萘洛尔治疗的甲状腺功能亢进患者中发现羟脯氨酸尿排泄量显著降低。普萘洛尔对羟脯氨酸尿的这种作用与这些患者中观察到的血清T3浓度降低程度无关。
