Beylot M, Vincent M, Benzoni D, Bodson A, Riou J P, Mornex R
Nouv Presse Med. 1982 Mar 20;11(13):989-91.
Hydroxyproline excretion was increased by hyperthyroid patients. This increase was related to thyroid hormone levels. Propranolol administration induced a decrease in hydroxyproline excretion and in immunoreactive triiodothyronine. Indometacin administration induced a decrease in urinary excretion of prostaglandins but had no effect on hydroxyproline excretion. These data suggest that the increased bone resorption of hyperthyroidism may involve a catecholamine beta receptor-dependent mechanism and is probably independent of prostaglandins.
甲状腺功能亢进患者的羟脯氨酸排泄量增加。这种增加与甲状腺激素水平有关。给予普萘洛尔可导致羟脯氨酸排泄量和免疫反应性三碘甲状腺原氨酸减少。给予吲哚美辛可导致前列腺素尿排泄量减少，但对羟脯氨酸排泄无影响。这些数据表明，甲状腺功能亢进时骨吸收增加可能涉及一种儿茶酚胺β受体依赖性机制，且可能与前列腺素无关。
